Description
Technical & Manufacturing Relevance:
Essential for normal blood coagulation via activation of clotting factors II, VII, IX, and X
Contributes to bone health through osteocalcin activation
Primary clinical and supplemental form of vitamin K
High potency at microgram levels → requires precise dilution and blend uniformity
Fat-soluble; absorption enhanced with oils/emulsifiers
Commonly combined with vitamin D₃ and calcium in bone-health formulations
Supplied as oil concentrate or spray-dried / cold-water-soluble (CWS) powder
Applicable Dosage Forms:
Tablets and capsules
Softgels
Powders, granules, and sachets
Oral drops and syrups
Multivitamin–mineral premixes
Fortified foods and nutritional beverages
Injectable formulations (pharmaceutical grade only)
Pharmacopoeial / Quality Notes:
Available in grades compliant with USP / EP / BP / IP / FCC
Yellow to yellow-green crystalline powder or oily liquid
Practically insoluble in water; soluble in oils and organic solvents
Light and oxidation sensitive; antioxidant systems and light-resistant packaging required
Manufactured in GMP-certified facilities with validated potency testing (HPLC)
Animal-Origin Declaration:
Non-animal origin (plant-derived or synthetic)
BSE/TSE free; vegan-suitable grades available
Non-GMO (grade dependent)
Manufacturing Support:
Supplied with COA, SDS/MSDS, TDS, potency calculation sheet, and origin declaration
Technical support for µg-level standardization, dilution accuracy, and formulation stability
Regulatory and documentation support available for global resale, export, and international distribution
Suitable for pharmaceutical, nutraceutical, food supplement, and clinical-nutrition manufacturing worldwide, subject to local regulatory approvals
Important Note:
Phytonadione (Vitamin K₁) is a high-potency fat-soluble vitamin. Usage must follow validated micro-dosing and stability controls and comply with country-specific vitamin K RDA/AI guidelines, particularly in populations using anticoagulant medications.
