Description
Technical & Manufacturing Relevance:
Essential for normal blood coagulation via activation of clotting factors (II, VII, IX, X)
Plays a role in bone metabolism through osteocalcin activation
Primary dietary and supplemental form of vitamin K
Highly potent at microgram doses, requiring precise dilution and blending
Fat-soluble; absorption enhanced when formulated with oils or emulsifiers
Commonly combined with vitamin D₃ and calcium in bone-health formulations
Supplied as oil concentrate or spray-dried / cold-water-soluble (CWS) powder
Applicable Dosage Forms:
Tablets and capsules
Softgels
Powders, granules, and sachets
Oral drops and syrups
Multivitamin–mineral premixes
Fortified foods and nutritional beverages
Injectable formulations (pharmaceutical grade only)
Pharmacopoeial / Quality Notes:
Available in grades compliant with USP / EP / BP / IP / FCC
Yellow to yellow-green crystalline powder or oily concentrate
Practically insoluble in water; soluble in oils and organic solvents
Sensitive to light and oxidation; antioxidant protection and light-resistant packaging required
Manufactured in GMP-certified facilities with validated potency testing (HPLC)
Animal-Origin Declaration:
Plant-derived or synthetic non-animal origin
BSE/TSE free, non-GMO (grade dependent)
Vegan-suitable grades available
Manufacturing Support:
Supplied with COA, SDS/MSDS, TDS, potency calculation sheet, and origin declaration
Technical support for µg-level standardization, dilution accuracy, and blend uniformity
Regulatory and documentation support available for global resale, export, and international compliance
Suitable for pharmaceutical, nutraceutical, food supplement, and clinical-nutrition manufacturing worldwide, subject to local regulatory approvals
Important Note:
Phylloquinone is a high-potency fat-soluble vitamin. Formulation must follow validated micro-dosing and stability controls, and usage must comply with country-specific vitamin K RDA/AI guidelines, especially considering interactions with anticoagulant medications.
