Description
Technical & Manufacturing Relevance:
Clinically established form of vitamin K₂, widely used in pharmaceuticals (notably in bone health)
Activates osteocalcin and matrix Gla-protein (MGP), supporting bone mineralization and inhibiting vascular calcification
Shorter half-life than MK-7; often formulated at higher or divided doses
Synergistic with vitamin D₃, calcium, and magnesium
Fat-soluble; absorption enhanced with oils or emulsified systems
Requires µg-level dosing accuracy and light/oxygen protection
Supplied as oil concentrate, adsorbed powder, or spray-dried/CWS form
Applicable Dosage Forms:
Tablets and capsules
Softgels
Powders, granules, and sachets
Oral drops and liquids
Multivitamin–mineral premixes
Clinical and therapeutic nutrition formulations
Pharmacopoeial / Quality Notes:
Available in grades compliant or aligned with USP / EP / BP / IP (MK-4 monograph availability varies by region)
Yellow to orange crystalline powder or oily liquid
Practically insoluble in water; soluble in oils and organic solvents
Light- and oxidation-sensitive; antioxidants and light-resistant packaging recommended
Manufactured in GMP-certified facilities with validated potency testing (HPLC)
Animal-Origin Declaration:
Non-animal origin (synthetic/bioidentical)
BSE/TSE free; vegan-suitable grades available
Non-GMO (grade dependent)
Manufacturing Support:
Supplied with COA, SDS/MSDS, TDS, potency calculation sheet, and origin declaration
Technical support for µg-level standardization, dilution accuracy, and stability management
Regulatory and documentation support for global resale, export, and international compliance
Suitable for pharmaceutical, nutraceutical, food supplement, and clinical-nutrition manufacturing worldwide, subject to local regulatory approvals
Important Note:
Menatetrenone (Vitamin K₂ MK-4) is a high-potency fat-soluble vitamin. Formulation must follow validated micro-dosing and stability controls, and use should comply with country-specific vitamin K guidelines, particularly for individuals using anticoagulant medications.
