Description
Technical & Manufacturing Relevance:
Plays a critical role in calcium metabolism, directing calcium to bones and teeth and away from soft tissues
Activates osteocalcin and matrix Gla-protein (MGP), essential for bone density and cardiovascular health
Longer biological half-life than vitamin K₁, especially MK-7 → allows lower daily dosing
Widely used in bone, cardiovascular, and metabolic health formulations
Synergistic with vitamin D₃, calcium, and magnesium
Requires microgram-level dosing accuracy
Supplied as oil concentrate, spray-dried / CWS powder, or adsorbed beadlets
Applicable Dosage Forms:
Tablets and capsules
Softgels
Powders, granules, and sachets
Oral drops and liquids
Multivitamin–mineral premixes
Fortified foods and nutritional beverages
Pharmacopoeial / Quality Notes:
Available in grades aligned with USP / EP / BP / IP / FCC (vitamin K₂ specifications; monograph availability varies by MK type)
Yellow to orange crystalline powder or oily liquid
Practically insoluble in water; soluble in oils and organic solvents
Sensitive to light, heat, and oxidation → antioxidant protection and light-resistant packaging required
Manufactured in GMP-certified facilities with validated potency testing (HPLC)
Animal-Origin Declaration:
Typically fermentation-derived (natto bacteria) or synthetic
Non-animal origin, BSE/TSE free
Vegan-suitable grades available (especially MK-7)
Non-GMO options available
Manufacturing Support:
Supplied with COA, SDS/MSDS, TDS, potency calculation sheet, and origin declaration
Technical support for µg-level standardization, dilution accuracy, and blend uniformity
Regulatory and documentation support available for global resale, export, and international compliance
Suitable for pharmaceutical, nutraceutical, food supplement, and clinical-nutrition manufacturing worldwide, subject to local regulatory approvals
Important Note:
Menaquinone (Vitamin K₂) is a high-potency fat-soluble vitamin. Formulation must follow strict micro-dosing and stability controls. Usage must comply with country-specific vitamin K guidelines, especially for individuals using anticoagulant medications.
